Imodzi mwa matenda omwe akukula kwambiri padziko lapansi, popanda kusiyanitsa, ndi kunenepa kwambiri. Lero, ndi mwayi womwe tili nawo kuti tipeze zomwe tikufuna, potengera chakudya, anthu ambiri akudya zambiri, zopangidwa ndi mafuta komanso kuchita masewera olimbitsa thupi pang'ono. Ndipo fayilo ya Sibutramine ndi amodzi mwamankhwala omwe angakuthandizeni kulimbana ndi kunenepa kwambiri.
Ogwirizana ndi izi, ambiri akakhala kuti ali ndi vuto la kunenepa kwambiri, kapena atakhala onenepa kwambiri, sangathe kuchita masewera olimbitsa thupi, chifukwa matupi awo sangatengere ... Ndipo vuto lakuchepetsa zomwe amadya ndilonso lalikulu kwambiri.
Ndipo ndikuganiza za izi, zamomwe tingathandizire anthu omwe akuvutika ndi kunenepa kwambiri, komanso momwe angapindulire nawonso, makampani opanga mankhwala adapanga mankhwala omwe angathandize anthuwa.
Ndipo imodzi mwa mankhwalawa ndi hydrochloride wa Sibutramine, wodziwika bwino monga Sibutramine. Ndipo ndi za mankhwalawa omwe tidziwa m'nkhaniyi ndikumvetsetsa ngati angathandizedi kuonda e kulemera.
Sibutramine ndi chiyani?
O sibutramine hydrochloride buy ndi serotonin yosankha ndi noradrenaline reuptake inhibitor yogwiritsidwa ntchito ndi madokotala ngati njira yochepetsera kunenepa kwambiri.
Mankhwalawa amapangidwa kuti akhale chowonjezera mu a zakudya de zopatsa mphamvu kuchepetsa, zomwe zimathandizira kukulitsa kuonda poyerekeza ndi zomwe zinatheka posintha kudya kokha.
O sibutramine hydrochloride mtengo sichidziwika ngati mankhwala osokoneza bongo, koma polimbikitsa kuchepa kwamafuta pang'onopang'ono, mosatekeseka komanso kosalekeza, komwe kumasungidwa kwakanthawi.
m'mbiri
O sibutramine hydrochloride ndi imodzi mwamankhwala aposachedwa kwambiri ochepetsa kulemera pamsika waku US, kulandira chilolezo cha Food and Drug Administration (FDA) mu 1998. Amagulitsidwa ku US pansi pa dzina la Meridia.
Chogulitsachi chinapangidwa ndi Abbott Laboratories, yomwe imagulitsanso m'maiko ambiri omwe amatchedwa Reductil (kuphatikiza Brazil).
A mtengo wa sibutramine amawerengedwa kuti ndi chinthu chowongoleredwa chifukwa chimakhala ndi zovuta zina zalamulo pakugawana kapena kukhala nazo.
Mankhwalawa siotchuka kwambiri kwa othamanga, ngakhale amawoneka ambiri m'magulu okhudzana ndi ochita masewera olimbitsa thupi omwe akufuna kuonda.
Zotsatira Ziti za Sibutramine?
hydrochloride wa sibutramine kugula masewera a kuwonda kudzera munjira ziwiri zosiyana:
- Choyamba ndikuti chimakhala ndi chilakolako champhamvu chofuna kudya. M'maphunziro ena, odwala adachepetsa kudya kwawo kwa tsiku ndi tsiku mpaka makilogalamu 1.300 (ochepa kwambiri) pomwa mankhwalawa.
- Chachiwiri ndi chakuti sibutramine imalimbikitsanso mitsempha yamatenda chifukwa chake, kugwiritsa ntchito ma calories tsiku lililonse. Mlingo umodzi wa 10 mg wawonetsedwa kuti umawonjezera kuchuluka kwa metabolic mpaka 30%, zotsatira zomwe zimasungidwa kwa maola osachepera asanu ndi limodzi. Izi thermogenic kanthu amadziwika kuti zimachitika kudzera dongosolo adrenergic, makamaka kudzera m`njira zina thandizo la beta 3 cholandilira kutsegula.
Pogwiritsira ntchito mankhwalawa, tidzawona kuwonjezeka kwakukulu kwa thermogenesis mu minofu ya brown adipose, (BAT), yomwe imatsagana ndi kuwonjezeka kwa kutentha kwa thupi kwa 0,5 degrees Celsius.
Kukula kwa kutentha kwa thupi ndi chisonyezo chabwino kuti thermogenesis ikuchitika, yomwe mungamvetse ngati mawonekedwe omwe tikufuna, nawonso, tikamamwa chiwelits.
Kuti mudziwe bwino momwe sibutramine imagwirira ntchito, titha kutenga kafukufuku kuchokera Kansas Foundation for Clinical Pharmacology 2001, komwe gulu la odwala 322 onenepa limalandira 20mg ya sibutramine kapena placebo kamodzi patsiku kwa masabata 24.
Mapeto a kafukufukuyu anali kuti 42% ya odwala omwe ali mgulu la sibutramine adataya 5% kapena kuposa kulemera kwawo koyamba, pomwe 12% adazindikira kutayika kwa 10% kapena kupitilira apo.
Sibutramine yakhala ikugwirizananso ndi kusintha kwa serum triglycerides ndi shuga wamagazi. mafuta HDL, yomwe inali ikuwonetsa zofooka poyambira.
Kafukufuku wina mwatsatanetsatane adamalizidwa ku China ndi department of Endocrinology ku Rui-jin Hospital mchaka chomwecho ndipo adangotenga 10 mg patsiku la sibutramine pagulu la amuna ndi akazi 120. Kafukufukuyu analinso wofunikira, pomwe odwala amataya pafupifupi 6,5 kg pofika sabata la 24th.
Kodi zimaperekedwa bwanji?
Sibutramine hydrochloride amapezeka kwambiri mu 5mg, 10mg ndi 15mg makapisozi.
Zomangamanga?
Sibutramine hydrochloride ndi serotonin norepinephrine yomwe imagwira ntchito yolimbana ndi amphetamine.
Amakhala ndi mankhwala osakanikirana a (+) ndi (-) 1- (4-chlorophenyl) -N, N-dimethyl-α- (2-methylpropyl) -cyclobutanemethanamine.
Zotsatira zoyipa?
Zotsatira zoyipa kwambiri ndi sibutramine ndi kuthamanga kwa magazi, chinthu chomwe chimatsutsana ndi momwe amagwiritsidwira ntchito kwa odwala omwe ali ndi kuthamanga kwa magazi kapena vuto lina lamtima.
Sibutramine hydrochloride iyenera kuyimitsidwa nthawi yomweyo ngati ili ndi vuto lililonse Zotsatira zoyipa zizindikiro zowopsa kwambiri zimachitika kapena ngati zizindikiro za:
- Kawopsedwe;
- Kuphatikizapo chisangalalo;
- Kusakhazikika;
- Kutaya chidziwitso;
- Chisokonezo;
- Kusokonezeka;
- Zofooka;
- Kugwedezeka;
- zonyansa;
- Kuchuluka kwa kugunda kwa mtima;
- Ophunzira osokonekera;
- Kusanza;
- Kupuma kovuta;
- Zowawa pachifuwa;
- Kutupa kwa mapazi;
- Ankolo kapena miyendo;
- Kukomoka;
- Kusokonezeka;
- Matenda okhumudwa;
- Kutentha thupi;
- Kupweteka kwa diso;
- Kugwedezeka;
- thukuta kwambiri.
Zotsatira zina zoyipa zimaphatikizapo kamwa youma, kusowa tulo, kukwiya, kupweteka kwa msana, m'mimba ndi kudzimbidwa.
Zisonyezo ndi momwe mungagwiritsire ntchito?
Sibutramine hydrochloride imavomerezedwa ndi Food and Drug Administration (FDA) kuti iwongolere kunenepa kwambiri, kuphatikiza kuchepa ndi kusamalira, ndipo iyenera kugwiritsidwa ntchito limodzi ndi chakudya chochepetsedwa ndi kalori.
Mankhwalawa atha kugwiritsidwa ntchito ndi odwala omwe ali ndi zoopsa zina zowonjezera, kuphatikizapo matenda oopsa, matenda ashuga, ndi dyslipidemia (cholesterol).
Mlingo woyambira woyamba wa odwala ambiri ndi 10 mg kamodzi patsiku, zomwe zimayenera kusinthidwa kukhala 15 mg pakatha milungu inayi ngati kuchepa thupi sikunayambike mokwanira. Mlingo wapamwamba samalimbikitsidwa.
Mungapeze kuti?
Popeza kunenepa kwambiri ndi vuto lomwe limapezeka ku UK ndi US, kuchuluka kwa zolembedwa zamankhwalawa chaka chilichonse ndikokwera kwambiri.
Pali madotolo ndi zipatala zambiri zomwe zimagwiritsa ntchito mankhwala ochepetsa thupi, ena omwe amatha kutumiza mankhwalawo kudzera pamakalata (kutengera malamulo amderalo).
Ku Brazil, Sibutramine 15 mg yokhala ndi makapisozi a 30 (generic) amatha kupezeka ochepera 30 reais m'maketoni ena azamalonda, pakukweza komwe kumachitika nthawi ndi nthawi. Komabe, popeza ndi mankhwala okhala ndi mzere wakuda, amafunikira mankhwala kuti mugule.
Mutha kugula, osafunikira mankhwala, patsamba la intaneti. Mtengo ndiwokwera pang'ono, koma ndiwothandiza chifukwa simukusowa mankhwala (zomwe zingakupangitseni ndalama zambiri kuti mupite kwa dokotala).
Komabe,
Munkhaniyi mutha kuphunzira zambiri za sibutramine, mankhwala ogwiritsidwa ntchito kwambiri omwe ali ndi zotsatira zenizeni… Komabe, ndi mankhwala owopsa, chifukwa cha zovuta zake zambiri.
Chifukwa chake ngati mukufufuza za mankhwalawa kuti muwagwiritse ntchito. Ndikupangira kuti muzitsatira. Nthawi zonse kumbukirani: thanzi lanu ndilofunika kwambiri kuposa chiopsezo chilichonse chomwe mungatenge.
Za Post Author
nsonga zabwino zowonjezera.